Fig. 3: Interactions often affect both the additive and dominance effects of involved loci.
From: The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross
a Interaction plots of all two-locus (left) and three locus (right) effects for two representative environments. Significant interactions between loci are shown as connecting lines. Green bars are the absolute effect size of a locus, calculated as the absolute difference between the mean fitness of diploids that are 3S/3S and BY/BY at the focal locus. Orange bars are the number of interactions detected for each locus. b Scatter plot of the absolute effect size of a locus and the number of two-locus (left) and three-locus (right) interactions in which it is involved. Local regressions are shown as blue lines. c Scatter plot of the number of two-locus and three-locus interactions per locus. d Examples of genetic interactions with, from left to right, low (0.04), moderate (0.48), and high (0.97) fractions of epistasis involving dominance. All genotype classes had n > 8,700. Black lines are the mean fitness of diploids subsetted by the genotype state at the two involved loci. Gray lines are the standard errors. Green lines are the expected mean fitness of heterozygotes assuming no dominance. Genotype state at each locus is denoted by colored boxes: BY/BY (blue), 3S/3S (orange), is BY/3S (half blue, half orange). The first locus is the locus whose effect is being modified, and the second locus is the modifier locus. Dominance and additive effects (blue and red bars, respectively) for each subset of the data are shown next to the relevant genotype classes. e Density plot of the fraction of epistasis involving dominance for all interactions (red; n = 3,522 genetic interactions), hub-hub (yellow; n = 87), non-hub-hub (blue; n = 2197), hub-non-hub (green; n = 2197), and non-hub-non-hub interactions (purple; n = 1,238).
