Fig. 4: Multiple modifier loci cause hubs to exhibit a range of effect sizes across different genetic backgrounds.
From: The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross
a Specific examples of hubs on Chromosome VI, X, and XII (each row) and their additive (left) and dominance (right) modifiers. The height of the bar corresponds to the magnitude of the modifying effect. The dotted red line shows the threshold in which loci were considered as major effect modifiers. b Barplot showing the total number of times loci were detected as a major effect modifier of additive (left) or dominance (right) effects of hubs across environments. Colored dots indicate hub loci. An asterisk indicates a non-hub locus on ChrIII. c Additive (top; n > 443 for each genotype class) or dominance (bottom; n > 175 for each genotype class) effect size of Chromosome VI hub in NaCl across different allelic combinations of its four largest effect modifiers. Red points are the mean effect size of a genotype class based on the genotype state of the four modifiers. Black point is the overall mean effect size of the locus. Black lines are bootstrapped 95% confidence intervals.
