Fig. 2: BMP signaling shows highly organized distribution in gastric glands, with strong expression in the pit cells and absence or inhibition in the gland base. | Nature Communications

Fig. 2: BMP signaling shows highly organized distribution in gastric glands, with strong expression in the pit cells and absence or inhibition in the gland base.

From: BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation

Fig. 2

a–c Single-molecule in situ hybridization (sm-ISH) for Bmp2, Bmp4, Bmp6, and Bmp7 in antrum tissue (n = 3). d, e High magnification and quantification for Bmp2 and Bmp4 signal area per picture divided into top, middle, and base of the gland (n = 3). f Sm-ISH for Grem1, Grem2, and Chrdl1 in antrum tissue with high magnification of the gland base (n = 3). g Sm-ISH for Noggin in antrum tissue. h Quantification for Grem1, Grem2, and Chrdl1 signal area per picture divided for top, middle, and base (n = 3). Images are representative of at least three biological replicates. Scale bar: 100 µm. Data are presented as mean ± SEM. Statistical analyses were performed using one-way ANOVA, followed by Tukey’s multiple comparisons test for (d, e, h). Source data are provided as a Source Data file.

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