Fig. 6: Deficiency of BMP signaling blocks the BMP feedback loop and promotes gland hyperplasia. | Nature Communications

Fig. 6: Deficiency of BMP signaling blocks the BMP feedback loop and promotes gland hyperplasia.

From: BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation

Fig. 6

a Sm-ISH for Id1 and quantification of Id1 signal area per image in antrum tissue from WT (n = 3) and Axin2CreErt2/Bmpr1afl/fl (n = 3) mice. b Sm-ISH for Bmp2 and quantification of Bmp2 signal area per image in antrum tissue from WT (n = 3) and Axin2CreErt2/Bmpr1afl/fl (n = 3) mice. c Immunofluorescence images of antrum tissue from WT (n = 3) and Axin2CreErt2/Bmpr1afl/fl (n = 3) mice. Gland height of antrum tissue and relative abundance of the Ki67+ and GSII+ compartments were quantified. Images are representative of at least three biological replicates. Scale bar: 100 µm, data are presented as mean ± SEM. Statistical analyses were performed using Student’s t-test (two-tailed) for (a–c). Source data are provided as a Source Data file.

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