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a Hybrid binding by S9.6. b Hybrid binding by human RNase H1 with a zoomed-in view of the phosphate-binding pocket (PDB 2QK9 (ref. 45)). c Hybrid binding by Thermovibrio ammonificans RNase H3 with a zoomed-in view of the phosphate-binding pocket (PDB 4PY5 (ref. 81)).