Fig. 6: Illustration of compartmental gHAT model.
The multi-host gHAT model is composed of one host species able to confer gHAT (humans), a further non-reservoir species (others) and tsetse. After the incubation period, infected human hosts follow the progression which includes infectious stage 1 disease, I1H, infectious stage 2 disease, I2H, and non-infectious (due to hospitalisation) disease, R. Pupal stage tsetse, PV, emerge into unfed adults. Unfed tsetse are susceptible, SV, and following a blood meal become either exposed, EV, or have reduced susceptibility to the trypanosomes, GV. Tsetse select their blood meal from one of the host types dependant upon innate feeding preference and relative host abundance. High-risk humans are more likely to receive bites than low-risk humans. Any blood meals taken upon “other” hosts do not result in infection. The transmission of infection between humans and tsetse is shown by grey paths. This figure is adapted from the original model schematic25, which was published under a CC-BY licence.
