Fig. 3: Genetic interactions between Sbds, Efl1, and eIF6.
From: eIF6 rebinding dynamically couples ribosome maturation and translation
a Increased eIF6 dosage enhances the growth defects of Sbds-deficient Drosophila. Flies were photographed at 1, 3, 5, and 11 days after egg laid. Scale bar, 1 mm. b Genetic interactions between Sbds, Efl1, and eIF6 in the Drosophila eye. Representative photomicrographs of adult eyes from flies with the indicated genotypes. EES, abbreviation of (eIF6/+, Efl1RNAi/+, SbdsRNAi/+). Scale bar, 100 μm. c Overexpression of eIF6 suppresses global protein synthesis in Drosophila wing disc cells. Third instar larval wing disc cells with the indicated genotypes were immunostained to reveal OP-Puro incorporation (red, gray). Posterior wing disc cells are marked with GFP; nucleus is blue (DAPI), scale bar: 100 μm. Data are representative of three independent experiments including ten wing discs each.
