Fig. 1: Multi-omics profiling of childhood ALL cell lines. | Nature Communications

Fig. 1: Multi-omics profiling of childhood ALL cell lines.

From: Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines

Fig. 1

a Schematic workflow of childhood ALL cell lines data generation and analyses conducted in this study. Cells were profiled for protein level using mass spectrometry and mRNA expression using RNA-seq. The majority of the cell lines, excluding derivative or sister cell lines (n = 43) were scanned for their sensitivity to 528 investigational and oncology drugs. b An overview of the most prominent molecular features of the 51 cell lines in this panel. BM bone marrow, PB peripheral blood, PE peripheral effusion, DSRT drug sensitivity and resistance testing. c Principal component analysis (PCA) of the highly variable proteins in the 51 cell lines showed distinct clusters corresponding to BCP-ALL (green), immature B-ALL (blue), T-ALL (pink), and EBV-transformed B cells (gray). d Cell lines grouped by the most prominent features of the described cytogenetic subtypes using proteomics data. BR biological replicate. Source data are provided as a Source Data File 1.

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