Fig. 5: Circulating IFN-γ levels modeled to circulating IgG levels against RBD in individuals vaccinated against SARS-CoV-2.
From: Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors
Distribution of circulating IgG levels, represented in log(AU/ml), over time (days from the first vaccine) in individuals vaccinated with BNT162b2 (left) or with the combination ChAdOx1/BNT162b2 (right). Circles and triangles represent the observed levels of circulating IgG levels for non-previously infected and infected individuals with SARS-CoV-2, respectively. Solid and dashed lines represent the predicted levels of circulating IgG levels for non-previously infected and infected individuals with SARS-CoV-2, respectively. Black, yellow, and blue colors represent low, intermediate, and high levels of IFN-γ released from stimulated T-cells against peptides derived from the S1 subunit of S protein. Black dotted line represents the threshold for assay positivity. Shadowed areas represent the 95% confidence interval. Center for the confidence interval is the predicted (mean) values.
