Fig. 3: Anti-PvCS LSP antibody response in naive and semi-immune volunteers. | Nature Communications

Fig. 3: Anti-PvCS LSP antibody response in naive and semi-immune volunteers.

From: Randomized clinical trial to assess the protective efficacy of a Plasmodium vivax CS synthetic vaccine

Fig. 3

Kinetics of specific IgG response to N, R, and C fragments in both Exp (n = 11) and Ctrl (n = 5) volunteers in Naive (a) and Semi-immune groups (b). Sterilely protected volunteers are shown in red lines and non-protected in blue lines. Symbols indicate IgG titer as log10 of ELISA values throughout the 10 months of the study. Black triangles at the bottom of the figure indicate immunizations (at 0, 2, and 6 months) and black arrows the controlled human malaria infection (CHMI, at month 9). Significant boosting of antibodies to the three fragments was higher in the naive than in the semi-immune groups (N-, p = 0.046; R-, p = 0.0013; C-, p = 0.00505). Antibody titers did not associate with infection intensity in the naive group (N, p = 0.72; C, p = 0.55; R, p = 0.65) or semi-immune group (N, p = 0.98; C, p = 0.73; R, p = 0.52). Source data are provided as a Source data file.

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