Fig. 6: Comparisons of efficacy between 2-SPARSE and a conventional virus expression system in the AUD.
From: Brain-wide projection reconstruction of single functionally defined neurons
a All reconstructed neurons labelled by 2-SPARSE (neurons #1–13; cyan) or a conventional virus expression system (neurons #23–28; pink). The neurons were registered to the standard Allen Brain Atlas and are shown with horizontal view. b Dendritic morphologies of five reconstructed neurons (corresponding to the pink neurons in (a) labelled with a conventional virus. All neurons are located in the L2/3 and displayed in different colours. The grey dashed lines indicate the laminar borders. c Comparisons of dendritic and axonal lengths and total numbers of axonal and dendritic branches between the neurons labelled by 2-SPARSE (n = 13 neurons) and the conventional virus expression system (n = 6 neurons). The data with error bars represent the mean ± SEM. P = 0.8314, P = 0.3556, P = 0.4155, and P = 0.4524 for the dendritic length, dendrite branch number, axon length, and axon branch number comparisons, respectively; two-sided Wilcoxon rank-sum test, n.s., P > 0.05.
