Fig. 6: Transcriptomic changes in human kidney proximal tubular HK-2 cells following treatments with polymyxin B (PMB), colistin (COL), F287, F319, and F365.
From: A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens
a Numbers of differentially expressed genes. Distinctive intersections are color-coded. b Cell viability difference (two-tailed Student’s t-test, n = 4 biologically independent cells, Benjamini–Hochberg adjusted P-values) between wild-type HK-2 and KCNJ16 knockout (KO) cells following 24 h treatment with lipopeptides. n.s., not significant; *adjusted P < 0.05, **adjusted P < 0.01, ***adjusted P < 0.001. Data are shown as mean ± s.d. and individual data points. c Extracted transcriptional regulatory network from Signor database with 1-step neighbor constraints (enlarged for detail). Source data are provided as a Source Data file.
