Fig. 3: RCOR1 is enriched in proximal promoters of active genes.
From: Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin
a Venn diagram showing the number of ChIP-seq peaks of RCOR1, LSD1, and HDAC1 on K562 cells. b Enrichment of ChIP-seq peaks on DNA elements over the natural abundance of these elements across the genome. Dashed violet line shows enrichment over genome abundance. P values are shown next to each bar. c Genome-wide signal correlation heatmap showing the Spearman correlation coefficient between genome-wide signals of RCOR1 and different histone modifications. d Meta-gene profiling of RCOR1, LSD1, HDAC1, RNA POL-II, P300, and histone modifications in K562 cells. Upper plots show the normalized signal profiles for the occupancies of each protein or modification analyzed in different RCOR1 clusters. Lower plots show the signal heatmap from the genes in the four clusters. e Quartile-based comparison of relative occupancies of RCOR1, H3K4me3, H3K9ac, and P300 on RCOR1-sorted gene quartile groups.
