Fig. 4: Schematic overview of mevalonate pathways and lipid metabolism. | Nature Communications

Fig. 4: Schematic overview of mevalonate pathways and lipid metabolism.

From: The importance of biofilm formation for cultivation of a Micrarchaeon and its interactions with its Thermoplasmatales host

Fig. 4

The different pathways are indicated with dark blue (MVA pathway I), light blue (MVA pathway II), violet (MVA pathway III) and magenta arrows (MVA pathway IV), respectively. Names of enzymes are boxed. Enzymes expressed in Ca. Micrarchaeum harzensis and Ca. Scheffleriplasma hospitalis are indicated with black and grey circles. Abbreviations are AMPD anhydromevalonate phosphate decarboxylase, DGGGPS 2,3-bis-O-geranylgeranyl glycerol-1-phosphate synthase, DMD diphosphomevalonate decarboxylase, GGGPS 3-O-geranylgeranyl glycerol-1-phosphate synthase, GGPP geranylgeranyl diphosphate, GGPPS geranylgeranyl diphosphate synthase, G1PDH glycerol-1-phosphate dehydrogenase, IDI isopentenyl-diphosphate-delta-isomerase, IPK isopentenyl phosphate kinase, M3K mevalonate 3-kinase, M3P5K mevalonate 3-phosphate 5-kinase, MBD mevalonate-3,5-bisphosphate-decarboxylase, MVK mevalonate kinase, PMD phosphomevalonate decarboxylase, PMK phosphomevalonate kinase.

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