Fig. 2: During constant light and temperature cycles TIM and PER oscillations are strongly dampened in clock neurons of s-tim flies.
From: A natural timeless polymorphism allowing circadian clock synchronization in “white nights”
Averages of normalised TIM (a) and PER (b) levels (see “Methods”) in the different groups of clock neurons during day six of LLTC in y w; ls-tim (blue lines) and y w; s-tim flies (orange lines). Number of brain hemispheres/time points = 4–5. Error bars = sem (standard error of the mean). PER was not detectable in the 5th s-LNv of s-tim flies. A Mann–Whitney test was performed (with a Bonferroni correction) to compare s-tim ZT6 with the other time points to determine the significance of potential oscillations. For TIM, no significant oscillations were observed in the DN1 and DN3 groups. For PER, only the DN3 showed significant oscillations. In ls-tim all time points in (a) and (b) differed significantly from ZT12 (peak for TIM and trough for PER) apart from the l-LNv (b): * p < 0.05, ** p < 0.01, *** p < 0.0001. Source data are provided as a Source Data file.
