Fig. 3: Long-chain ceramides are enriched in murine and human skeletal muscle during metabolic disease. | Nature Communications

Fig. 3: Long-chain ceramides are enriched in murine and human skeletal muscle during metabolic disease.

From: Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle

Fig. 3

a Ceramide (Cer) 40:1 and Cer 42:1 in soleus muscle of low-fat diet (LFD) (red) and western diet (WD) (grey) fed mice (n = 8; two-tailed Student’s t test; Cer 40:1 P = 0.00056, Cer 42:1 P = 0.045). b Cer 40:1 and Cer 42:1 in plasma of LFD (red) and WD (grey) fed mice (LFD n = 6, WD n = 13; two-tailed Student’s t test; Cer 40:1 P = 0.00031). c Cer 40:1 and Cer 42:1 in skeletal muscle biopsies from patients with type 2 diabetes (T2D) (grey) and controls (red) (control n = 52, T2D n = 21; two-tailed Student’s t test; Cer 40:1 P = 0.033, Cer 42:1 P = 0.017). d Cer 40:1 and Cer 42:1 in blood plasma from patients with T2D (grey) and controls (red) (control n = 6, T2D n = 4; two-tailed Student’s t test; Cer 40:1 P = 0.0118, Cer 42:1 P = 0.012). *P ≤ 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Data in bar charts are expressed as mean ± SEM with individual data points. Box and whisker plots show 25th to 75th percentile (box) min to max (whiskers), mean (+) and median (−). Source data are provided as a Source Data file.

Back to article page