Fig. 3: Repertoire analyses of light chain variable regions in TC-mAb mice. | Nature Communications

Fig. 3: Repertoire analyses of light chain variable regions in TC-mAb mice.

From: Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci

Fig. 3

a Human VK gene utilization in hPBMCs of healthy donors and in TC-mAb mice with and without immunization (same as Fig. 2). b Circos plots comparing VJ gene association. Links indicate the relative frequencies of specific VJ combinations. The relative CDRL3 length (c), P and N nucleotide addition at joining positions (d), and amino acid usage (e) within the CDRL3 of productive rearrangements.

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