Fig. 5: Production of human Ig in TC-mAb mice. | Nature Communications

Fig. 5: Production of human Ig in TC-mAb mice.

From: Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci

Fig. 5

a The serum concentration of different classes of human Igs in 15-week-old TC-mAb mice. The concentration of hIg μ, hIg γ, hIg κ, mIg λ, hIg α and hIg ε in TC-mAb mice (n = 17) was measured. b The serum concentration of human IgG subclasses. The concentrations of Ig γ1, 2, 3 and 4 were measured in 15-week-old TC-mAb mice (n = 9). a, b Each symbol represents one serum concentration. c The serum concentration of hIg μ, Ig γ and Ig κ before and after immunization of TC-mAb mice. The symbols collected from the same mouse before and after immunization are connected by a line. d The number of lymphocytes. The numbers of harvested cells were counted under Turk’s solution. Each symbol indicates one mouse. Box plots are indicated in terms of minima, maxima, centre, bounds of box and whiskers, and percentile.

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