Fig. 4: ABE treatment restores the visual pathway from cones to the visual cortex.

a Representative visually evoked potentials (VEPs) from control Gnat1^−/−, treated rd12Gnat1^−/−, and untreated rd12Gnat1^−/− mice. b Population average of VEPs recorded from three groups in a. N total number of mice, n total number of recording sites from each experimental group. Shading indicates SEM. c VEP amplitudes recorded from three groups. Mean ± SEM. ***P < 0.001; two-tailed Mann–Whitney U-test. P values are 0.0004 for Gnat1^−/− vs. treated rd12Gnat1^−/− and <0.00001 for other comparison groups. d Response latencies of VEPs recorded from two groups. Mean ± SEM. Two-tailed Mann–Whitney U-test. e Raster plots and corresponding histograms for single neurons in Gnat1^−/− (n = 387 cells), treated (n = 286 cells), and untreated rd12Gnat1^−/− (n = 121 cells) mice, respectively. f Population average histograms for the same groups as e. Shading indicates SEM. Source data are provided as a Source data file.