Fig. 7: Graphical presentation of proposed mechanisms and relevance of basal cytokeratin induction in ESR1 mutant breast cancer. | Nature Communications

Fig. 7: Graphical presentation of proposed mechanisms and relevance of basal cytokeratin induction in ESR1 mutant breast cancer.

From: ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation

Fig. 7

ESR1 WT cells exhibit low basal cytokeratin expression with baseline insulated neighborhood prevalence spanning KRT14/16/17 loci. In contrast, a minor subpopulation of ESR1 mutant cells exhibit strong basal cytokeratin expression, due to PR activated enhancer at the KRT14/16/17 gene locus-spanning insulated neighborhoods. Increased expression of basal cytokeratin is associated with immune activation in ESR1 mutant tumor similar to that seen in basal tumors, at least in part mediated via enhanced S100A8/A9-TLR4 paracrine crosstalk between epithelial and stromal cells, including macrophages. Figure is generated using BioRender.

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