Fig. 3: Protein restriction protects against age-related functional decline via FGF21. | Nature Communications

Fig. 3: Protein restriction protects against age-related functional decline via FGF21.

From: FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice

Fig. 3

a Latency to fall from an accelerating rod (Rotarod) at 21 months of age in WT and Fgf21 KO mice on control or LP diets (n = 8–12 mice/group; geno*diet p = 0.008). b Grip Strength at 21 months of age (n = 8–12 mice/group; geno*diet p = 0.04). c Grip Strength normalized to body mass (n = 8–12 mice/group; geno*diet p = 0.01). d Ambulatory activity as measured in the metabolic chambers at 20 months of age (n = 8–12 mice/group geno*diet p = 0.39). e Locomotor activity as measured in the metabolic chambers at 20 months of age (n = 8–12 mice/group geno*diet p = 0.19). Statistical analyses were conducted using two-way ANOVA. All values are mean ± SEM, with significant posthoc comparison within the diet*genotype interaction noted as *p < 0.05 compared with respective control. Source data are provided as a Source Data file.

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