Fig. 1: Transcriptomic changes affecting the core AD processes of lipid metabolism, immune response, and synaptic function in the 3xTg hippocampus. | Nature Communications

Fig. 1: Transcriptomic changes affecting the core AD processes of lipid metabolism, immune response, and synaptic function in the 3xTg hippocampus.

From: Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model

Fig. 1

a Experimental paradigm for the whole-hippocampus bulk RNA sequencing experiment. b Heatmap of the 1114 Differentially Expressed Genes (DEGs, p ≤ 0.01) between 8-month-old WT and 3xTg hippocampus). c Volcano plot of the 632 downregulated DEGs (blue) and 482 up-regulated DEGs (red). d–f GO enrichment analysis showing the top 20 most enriched GO Biological Process gene sets (d, e) and the main GO molecular function nodes (f). The most significant (FDR ≤ 0.05) GO biological process gene sets for up-regulated DEGs were related to cellular responses to stimuli and the immune response (d) while those for the down-regulated DEGs were related to nervous system development and synapses (e). GO molecular function gene sets were only significantly enriched for down-regulated DEGs (FDR ≤ 0.1) and are illustrated by network plots that highlight lipid metabolism, membrane channel activity and ion binding (f). g–i Heatmaps of the DEGs that are related to lipid metabolism (g), immune response (h), and synaptic function (i) (see the “Methods” section). Refer to Supplemental Data File 1 for the complete DEG list and the lipid metabolism, immune response, synaptic function genes.

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