Fig. 6: Tumor secretory cDC align with the mature migratory cDC subset in HNSCC. | Nature Communications

Fig. 6: Tumor secretory cDC align with the mature migratory cDC subset in HNSCC.

From: PD-L1 and ICOSL discriminate human Secretory and Helper dendritic cells in cancer, allergy and autoimmunity

Fig. 6

A UMAP of the 10,503 cells analyzed by single-cell RNA sequencing displayed in 24 clusters. B, C Analysis of the 6 cDC/MMAC clusters as per 6A. B UMAP per cluster and expression of selected genes and antibody-derived tags (ADT). ADT staining was not present in all samples, see Methods for details. C Expression of the Tumor Secretory cDC2 signature. CD4 CD4 T cells, Conv conventional, TReg regulatory T cells, CD8 CD8 T cells, NK natural killer cells, pDC plasmacytoid DC, MMAC monocytes and macrophages.

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