Fig. 6: Association between SCNC subtypes and response to therapy. | Nature Communications

Fig. 6: Association between SCNC subtypes and response to therapy.

From: Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models

Fig. 6

a Kaplan–Meier curves of OS from the date of diagnosis in patients with tumors of NE and non-NE phenotypes. b Proportion of patients deriving clinical benefit from ATR inhibition and immunotherapy categorized by NE subtypes. Two-tailed chi-square, **P = 0.0024, *P = 0.0464. c Kaplan–Meier curves of PFS in patients treated with ATR inhibitor and immunotherapy categorized by subtypes. d Univariate and multivariate Cox proportional-hazard regression analyses of PFS in patients with NE tumors. e Kaplan–Meier curves of OS from the date of diagnosis in patients with NEv2-like subtype and others. HR and p-values by log-rank test are indicated. P-values marked with bold indicate statistical significance. Abbreviations: NE neuroendocrine differentiation; OS overall survival; HR hazard ratio; CI confidence interval; ATRi ataxia telangiectasia and Rad3-related inhibitor; ICI immune checkpoint inhibitor; PFS progression free survival.

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