Table 1 Enriched gRNAs in the MHC IIhigh population.

From: Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86

FC

log10(p value)

Gene

Name

gRNAs

6.04

7.313

March1

E3 ubiquitin-protein ligase MARCH1

2

5.82

8.362

Cbfb

Core-binding factor subunit beta

1

3.33

8.503

Ahr

Aryl hydrocarbon receptor

1

3.16

5.923

Ubl3

Ubiquitin-like protein 3

3

2.78

8.049

Kdm2b

Lysine-specific demethylase 2B

1

2.71

9.817

Runx3

Runt-related transcription factor 3

1

2.65

5.512

Ldb3

LIM domain-binding protein 3

1

2.54

6.780

Max

Protein max

1

2.51

5.556

Amn1

Antagonist of mitotic exit network 1

1

2.42

9.681

Runx1

Runt-related transcription factor 1

1

2.25

26.770

Mxi1

Max-interacting protein 1

1

2.19

9.306

Pcgf1

Polycomb group RING finger protein 1

2

  1. P values were assessed using a negative binomial generalized linear model with a two-sided likelihood ratio test, with adjustment for multiple testing using the Benjamini–Hochberg false discovery rate (FDR) method. Shown are hits with false discovery rate <0.01 and >2-fold enrichment over the reference library. FC fold change, gRNAs number of gRNAs detected.
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