Fig. 8: Quantile-Quantile plots of observed versus predicted −log10 P values for methylation differences with ART in CpGs associated with birthweight and neurodevelopment.
From: DNA methylation in newborns conceived by assisted reproductive technology
The observed −log10 P values on the y-axis (calculated from t statistics) were derived from two-sided t tests for: (a) the association between DNA methylation levels and birthweight on a continuous scale (in grams) and (b) the difference in DNA methylation levels between subjects with Mendelian neurodevelopmental disorders and controls. Blue dots indicate the P values for a subset of CpGs that have been reported to be significant for birthweight and neurodevelopmental disorders. For comparison, the P values for the overall associations of ART compared to naturally conceived are shown in gray. The diagonal lines indicate expected P values if there were no difference between the groups. Source data are provided as a Source Data file.
