Fig. 7: RAGE mediates mechanical strain-induced activation of innate immunity during infection. | Nature Communications

Fig. 7: RAGE mediates mechanical strain-induced activation of innate immunity during infection.

From: Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip

Fig. 7

a Illustration of the experimental protocol involving prophylactic treatment with signaling inhibitors for 48 h prior to viral infection of the human alveolus chip. b Graphs showing cytokine levels on chips. c Graph showing mRNA levels of H3N2 NP in epithelial cells treated with azeliragon or GSK2193874 at indicated doses on-chip. Data in b, c represent mean ± SEM; n = 3 biological chip replicates; one-way ANOVA with Dunnett’s multiple comparisons correction. Source data are provided as a Source Data file.

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