Fig. 5: Evaluation of Mn@CCs preferentially target the microscopic gliomas in an intracranial mouse model by fluorescent imaging. | Nature Communications

Fig. 5: Evaluation of Mn@CCs preferentially target the microscopic gliomas in an intracranial mouse model by fluorescent imaging.

From: Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors

Fig. 5

a The in vivo fluorescence images of U87MG glioma-bearing mice at different timepoints after intravenous administration of Mn@CCs (ex: 500 nm; em: filter dsRED). b The changes of the mean fluorescence intensity over time of Mn@CCs in brain parenchyma (n = 3 biologically independent animals). All the statistical data are expressed as mean values ± SD. The mean fluorescence intensity was calculated by ImageJ. c Ex vivo fluorescence images of organs excised at different timepoints post-i.v. injection of Mn@CCs. d Quantification of fluorescence signals of heart, liver, spleen, lung, kidney, and brain obtained from the ex vivo imaging data (ex: 500 nm; em: DsRed) (n = 3 biologically independent animals). All the statistical data are expressed as mean values ± SD. e Representative in vivo fluorescence image of the bladder area after i.v. injection of Mn@CCs at 1 h (ex: 500 nm; em: filter dsRED) (n = 3 biologically independent animals). f Fluorescent analysis of the urine samples obtained from the mice with and without injection.

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