Fig. 6: Evaluation of Mn@CCs preferentially target the microscopic gliomas in an intracranial mouse model by MR imaging. | Nature Communications

Fig. 6: Evaluation of Mn@CCs preferentially target the microscopic gliomas in an intracranial mouse model by MR imaging.

From: Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors

Fig. 6

a, b In vivo axial MR images of U87MG glioma-bearing mice at different timepoints after intravenous administration of Mn@CCs and Gd-DTPA. c, d Quantification of MRI signals in glioma at different timepoints of Mn@CCs (c) and Gd-DTPA (d) in a and b (n = 3 biologically independent animals). All the statistical data are expressed as mean values ± SD. Significant difference compared with control. *P < 0.05, ***P < 0.001. Statistical significance was assessed via unpaired two-tailed Student’s t-test. e Comparison of Mn@CCs and Gd-DTPA to image ability of microscopic glioma (n = 3 biologically independent animals). All the statistical data are expressed as mean values ± SD. *Significant difference compared with Mn@CCs and Gd-DTPA: 30 min (p < 0.001), 1 h (p = 0.002), 2 h (p = 0.008), 4 h (p = 0.023), respectively. *P < 0.05. Statistical significance was assessed via an unpaired two-tailed t-test. f, g In vivo coronal MR images of U87MG glioma-bearing mice at different timepoints after intravenous administration of Mn@CCs and Gd-DTPA. h, i Quantification of MRI signals in glioma at different timepoints of Mn@CCs (h) and Gd-DTPA (i) in f and g (n = 3 biologically independent animals). All the statistical data are expressed as mean values ± SD. Significant difference compared with control. *P < 0.05, ***P < 0.001. Statistical significance was assessed via unpaired two-tailed Student’s t-test. j Comparison of Mn@CCs and Gd-DTPA to image ability of microscopic glioma (n = 3 biologically independent animals). All the statistical data are expressed as mean values ± SD. *Significant difference compared with Mn@CCs and Gd-DTPA: 30 min (p < 0.001), 1 h (p < 0.001), 2 h (p = 0.003), 4 h (p = 0.042), respectively. *P < 0.05. Statistical significance was assessed via an unpaired two-tailed t-test. k H&E staining of glioma tissue slides from nude mice. l In vivo MR images of bladder at different timepoints. m Relative signal change of bladder at different timepoints based on MR imaging results (n = 3 biologically independent animals). All the statistical data are expressed as mean values ± SD.

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