Fig. 7: 3D imaging allows visualization of the distribution and penetration of Mn@CCs to tumors. | Nature Communications

Fig. 7: 3D imaging allows visualization of the distribution and penetration of Mn@CCs to tumors.

From: Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors

Fig. 7

a T1-weighted MR imaging was performed before and after injection of Mn@CCs in different stages of orthotopic GBM tumor-bearing mice (n = 3). Day 5, Day 10, Day 20, and Day 30: The days that tumor cells were inoculated after 5, 10, 20, and 30 days to image. b 3D view constructed from Mn@CCs enhanced MRI of microscopic orthotopic gliomas (green color) in the brain tissues (gray color) under different angles. c Assessment of different early-stages different early-stages tumor volume by Amira 2020.1 (Thermo Fisher Scientific, USA) and Clinical Eclipse Treatment Planning System (15.6) (n = 3 biologically independent animals). All the statistical data are expressed as mean values ± SD. d Process of clearing and imaging brain and identification of small tumor (small arrows). e Wide-field image of whole brain from orthotopic GBM tumor-bearing mice. Gray: brain tissue, red: RFP-expressed glioma, Green: Mn@CCs.

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