Fig. 9: 3D-genome organization conserved within syntenic blocks.
From: Anopheles mosquitoes reveal new principles of 3D genome organization in insects
a Scheme showing reordering of genomic segments as a result of evolutionary fixed chromosomal rearrangement. For each EBR between loci 1 and 4, we found corresponding regions 1–2 and 3–4 based on a synteny map of the ancestral species; b cePC1 values plot showing compartmental states of loci 1–4 in the ancestral genome. Each line represents cePC1 values for four loci (1, 2, 3, and 4). Quantification of differences between pairs of loci: 1 vs. 4, 2 vs. 4, and 1 vs. 3 are shown in Supplementary Fig. 26; c Hi-C contact frequencies of each species compared to syntenic An. coluzzii Hi-C contacts (OBS). Control provided for each species (RND) was obtained by random shuffling of contact frequencies within each genomic distance bin. L upper index indicates that species liftovered to An. coluzzii genomic coordinates; d. Conservation of the 3D-structure of the synteny block between An. coluzzii and An. albimanus species separated by 100 millon years; e Comparison of Hi-C maps of syntenic loci of An. coluzzii and An. stephensi. Dark blue—conserved features, light blue—modified ones. Color bars on d, e panels reflect the contact frequency.
