Fig. 1: Overall structures of Gq-coupled NMUR1/2 complexes bound to NMU and NMS. | Nature Communications

Fig. 1: Overall structures of Gq-coupled NMUR1/2 complexes bound to NMU and NMS.

From: Structural insights into the peptide selectivity and activation of human neuromedin U receptors

Fig. 1

a Sequence alignment of NMU and NMS created by CLUSTALW (https://www.genome.jp/tools-bin/clustalw) and ESPript 3.0 (https://espript.ibcp.fr/ESPript/cgi-bin/ESPript.cgi). b Schematic illustration of peptide-binding and Gq protein-coupling of NMURs. c–f Orthogonal views of the density maps and models of NMU-NMUR1-Gq-scFv16 (c), NMS-NMUR1-Gq-scFv16 (d), NMU-NMUR2-Gq-scFv16 (e), and NMS-NMUR2-Gq-scFv16 (f) complexes. NMS is shown in light blue, NMS-bound NMUR1 in orange, and NMS-bound NMUR2 in plum. NMU is displayed in green, NMU-bound NMUR1 in brown, and NMU-bound NMUR2 in hot pink. The Gq heterotrimer is colored by subunits. Gαq, purple; Gβ1, salmon; Gγ2, dark green; scFv16, grey. Gαq refers to mGαs/q/iN.

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