Fig. 2: The conserved binding pocket of NMUR2.
From: Structural insights into the peptide selectivity and activation of human neuromedin U receptors
a-c Cut-away view of NMU/NMS binding pocket of NMUR1 (a, b) and structural superposition of NMU and NMS in NMUR1 (c). d–f Cut-away view of NMU/NMS binding pocket of NMUR2 (d, e) and structural superposition of NMU and NMS in NMUR2 (f). The densities of NMS and NMU are shown. g-i Detailed interaction of NMU/NMS with residues in NMUR2. The binding site of N7U/S and R6U/S (g), P5U/S and R4U/S (h), F3U/S, L2U/S, F1U/S, and Y0U/F0U (i) are shown. Hydrogen bonds and salt bridges are depicted as orange dashed lines. NMU and NMS are shown as sticks. NMS is shown in light blue and NMS-bound NMUR2 in plum. NMU is displayed in green and NMU-bound NMUR2 in hot pink.
