Fig. 6: Intratumoral in situ assembly of D-NP/C-NP to deliver multiple agents for efficient cocktail chemoimmunotherapy.
From: Bioorthogonal in situ assembly of nanomedicines as drug depots for extracellular drug delivery
a Schematic illustrating the experimental protocol for cocktail chemoimmunotherapy in the 4T1 breast tumor model. b Individual and c average growth curves of 4T1 tumors (n = 5). d Images of lung tissues collected from mice after various treatments. e The number of metastatic lung nodules of mice bearing 4T1 tumors at the end of treatment. Data are presented as the mean ± s.d. (n = 5). Statistical significance was calculated via one-way ANOVA with a Tukey post hoc test in (c, e). *p < 0.05, ****p < 0.0001. f Survival rates of mice treated in different groups, n = 8 biologically independent animals. The statistical significance of the survival was calculated via log-rank (Mantel–Cox) test. ****p < 0.0001. i.v.: intravenously, PBS: phosphate-buffered saline. Source data are provided as a Source Data file.
