Fig. 4: PET imaging indicated that boronsome showed high accumulation in tumour but low uptake in other high-risk tissues.
From: Boron encapsulated in a liposome can be used for combinational neutron capture therapy
a Schematic representation of a mouse located at the beam terminal of the neutron irradiator. Tissues within radiation radius are marked as high-risk tissues (yellow). Tissues outside the radiation radius are marked as low-risk tissues (green). b Representative CT and PET-CT images of the female BALB/c mouse at various time points depicting [64Cu]Cu-NOTA-boronsome uptake. Tumours were circled with white dashed lines. c Time-dependent boron concentration in tumour, blood, lung, brain, muscle, fat, bone and heart post injection of boronsome (500 mg/kg, i.v.) measured by ICP-OES (n = 4). d Tumour-to-normal tissue ratios (T/N ratios) of organs 8 and 12 hours post once injection of boronsome (500 mg/kg, i.v., n = 4). Two-tailed unpaired Student’s t test, blood: **p = 0.0015, lung: **p = 0.0012, fat: ***p = 0.0003, heart: **p = 0.0026. e Corresponding biodistribution (n = 4) of [64Cu]Cu-NOTA-boronsome in 4T1 bearing mice 12 h post injection. f Tumour-to normal tissues ratios (T/N) (n = 4) by biodistribution at 12 h. Data are means ± SEM. Source data are provided as a Source Data file.
