Fig. 4: Overrepresentation analysis.

Panel A gives the percentage of each CRP-associated gene set that overlaps with selected genomic feature. Orange bars represent overlapping features by chance; green bars give the percentage that actually overlap with the CRP-associated CpGs. Transcription start site and enhancer genomic region were used as defined by the Roadmap project. HiC regions were as reported in GSE63525, where component A was connected to highly transcribed genomic regions and component B to heterochromatin. Panel B shows enrichment analysis between CRP-associated CpG that were significantly associated with mRNA expression. Empirical P-values for the overlap derived from a permutation test (described in more detail in method section “Overrepresentation analysis”) are given as negative log10. Percent overlap indicates the percentage of CpGs present in each GO term set. Panel C gives overlaps between CpGs observed in this study and published gene lists from large scale EWAS.