Fig. 5: Associations of CRP DNA methylation signature to clinically relevant phenotypes. | Nature Communications

Fig. 5: Associations of CRP DNA methylation signature to clinically relevant phenotypes.

From: DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases

Fig. 5

Forest plots give estimate from logistic regression (logODDs) and confidence intervals (error bars) of CpG risk score regression against relevant phenotypes. N is the number of samples included in analysis. To produce adjusted relative risk estimates we transformed odds ratios as follows: RR = odds ratio/1 − (lifetime risk) + (life time risk × odds ratio). Those estimates indicate the theoretical maximum impact of the discovered CpG signature (100% DNA methylation change) on the tested traits. The risk conveyed by one percent change in the DNA methylation risk score on the tested traits was 1.007% for COPD, 1.7% for T2D, 2.9% for myocardial infarction 4.3% coronary artery disease, and 0.2% for hypertension. For continuous traits such as FEV1, FVC, systolic BP, and blood glucose estimates from linear regression including confidence intervals are given.

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