Fig. 1: Generation of the PDX/CDX panel. | Nature Communications

Fig. 1: Generation of the PDX/CDX panel.

From: Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts

Fig. 1

a Overview of the patient-derived/circulating tumor cell-derived xenograft (PDX/CDX) cohort and clinical specimens. Samples were collected from surgical, pleural effusion, biopsy, autopsy, EBUS, Neuro Met, and CTC isolation and either engrafted into immunodeficient mice to generate PDX/CDX models or directly sent for targeted sequencing (MSK-IMPACT) and Immunohistochemistry (IHC). Created with BioRender.com. b Swimmers Plot depicting sample collection of the PDX/CDX cohort during treatment course (Platinum-based therapy— black arrow, Other therapy—gray arrow). Models derived from biopsies are annotated with a blue or gray dot (with next-generation sequencing [NGS] or not, respectively). Models derived from circulating tumor cells (CTC, sequenced with NGS) are annotated with an orange dot. Dark blue indicates NGS (MSK-IMPACT) for the clinical sample. Arrows are not to scale in terms of treatment duration.

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