Fig. 3: SCLC subtype annotation and neuroendocrine markers. | Nature Communications

Fig. 3: SCLC subtype annotation and neuroendocrine markers.

From: Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts

Fig. 3

a H&E and immunohistochemistry images for the indicated proteins are shown. Scale bar, 50 μM. Four representative tumors are shown. Three independent cores per sample were stained for H&E and the indicated protein with a representative example shown here. b Heatmap depicts H-scores derived from 37 scored patient-derived xenograft (PDX) tumors for the fraction of positive cells for each protein shown, as well as staining intensity. White box with a cross (MSK95, NCAM1) indicates staining failed. Source data are provided as a Source Data file. c Heatmap depicts H-scores derived from 18 paired PDX tumors and clinical samples for the fraction of positive cells for each protein shown, as well as staining intensity. White boxes with cross indicate no staining available. Source data are provided as a Source Data file. d Heatmap of gene expression of 43 PDX samples for the selected markers; ASCL1, NEUROD1, POU2F3, and YAP1. Color-coded panel on top depicts treatment status (naïve or treated) and subtype annotation based on immunohistochemistry (IHC) or RNA-sequencing. Source data are provided as a Source Data file.

Back to article page