Fig. 5: Gene expression signatures in SCLC. | Nature Communications

Fig. 5: Gene expression signatures in SCLC.

From: Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts

Fig. 5

Heatmap of gene expression of 43 patient-derived xenograft (PDX) samples for the selected gene signatures; neuroendocrine (NE) vs. non-NE gene signature32 (a), genes crucial in SCLC (b), EMT gene signature (c), MYC family gene expression (d), and metabolic gene signature42 (e). Color-coded panel on top depicts treatment status (naïve or treated) and subtype annotation based on IHC. Source data are provided as a Source Data file. f H&E and immunohistochemistry image for POU2F3 are shown for the clinical MSK773. Scale bar as indicated, 20 μM. g Genomic landscape in MSK773A (adenocarcinoma) vs. MSK773A (SCLC) samples representing putative driver alterations (i.e. excludes variants of unknown significance) in altered genes as detected by MSK-IMPACT20 targeted next-generation sequencing assay.

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