Fig. 3: α3KD caused the largest delta (δ, 1.5–4 Hz) effect in the longest NREM bouts before REM.
From: Knockdown of GABAA alpha3 subunits on thalamic reticular neurons enhances deep sleep in mice
a Analysis of non-rapid eye movement sleep (NREM) to rapid eye movement sleep (REM) transitions reveals larger delta power increases in longer NREM episodes, baseline (BL; blue) vs α3KD (red). Periods with stable delta (black bars), were tested for significance (one-tailed paired t-tests, *p < 0.05, n.s. not significant; p-values: 0.023; 0.028; 0.041; 0.039; 0.082.). The 24 s prior to NREM-REM transitions, when delta decays, were not included in statistical analyses. b Percent change in NREM delta power was positively correlated with NREM bout length prior to REM. P values from t-tests (BL vs α3KD) were negatively correlated with NREM bout length prior to REM as determined using Pearson’s linear correlation, two-tailed, ρ is Pearson’s linear correlation coefficient. Data from 12 h light period. N = 6. Color scales represent normalized power (power at time/power from wakefulness).
