Table 1 S. aureus N315 has 17 TCSs.
Gene name | Gene locus (SA number in N315) | Function/signal | Ref. | |
|---|---|---|---|---|
TCS1 | walKR | SA0018-SA0017 | Membrane permeability, cell-wall metabolism, autolysis | |
TCS2 | kdpDE | SA0067-SA0066 | K+ transport, virulence-related regulation, stress resistance | |
TCS3 | hptRS | SA0215-SA0216 | Hexose-phosphate transport | |
TCS4 | lytSR | SA0250-SA0251 | Autolysis, membrane electrical potential sensor, adaptation to cationic antimicrobial peptides | |
TCS5 | graSR | SA0615-SA0614 | CAMPs resistance, virulence, stress response, cell-wall signaling, growth at acidic pH | |
TCS6 | saeSR | SA0660-SA0661 | Regulation of exoprotein expression, virulence | |
TCS7 | SA1158-SA1159 | Unknown | ||
TCS8 | arlSR | SA1246-SA1248 | Autolysis, cell growth, agglutination, pathogenesis | |
TCS9 | srrBA | SA1322-SA1323 | Respiratory response, virulence | |
TCS10 | phoRP | SA1515-SA1516 | Phosphate starvation response (in B. subtillis); Growth during phosphate starvation | |
TCS11 | airSR | SA1667-SA1666 | Oxygen sensing and redox signaling | |
TCS12 | vraSR | SA1701-SA1700 | Vancomycin resistance; response to cell-wall-targeting antibiotics | |
TCS13 | agrCA | SA1843-SA1844 | Quorum sensing, virulence | |
TCS14 | kdpDE | SA1882-SA1883 | K+ transport, virulence-related regulation, stress resistance | |
TCS15 | hssSR | SA2152-SA2151 | Heme sensor system, virulence | |
TCS16 | nreCB | SA2180-SA2179 | Nitrite and nitrate reduction and transport | |
TCS17 | braSR | SA2417-SA2418 | Bacitracin and nisin resistance |
