Fig. 6: The highly negative charge of the CaSR dimer interface is variable.
From: Mechanism of sensitivity modulation in the calcium-sensing receptor via electrostatic tuning
a Electrostatic potential map of mGluR1 (top left, PDB 1ISR), mGluR5 (top right, PDB 3LMK), and CaSR (bottom left, PDB 5K5S). Close up inset of CaSR (bottom right) showing stick and surface representation of R227 and E228 at the lower lobe interface. b Multiple sequence alignment of mGluR1, CaSR, and select CaSR orthologs with negatively charged residues (red) and positively charged residues (blue) highlighted. CaSR is used as reference for residue numbering. Boxes indicate regions of high charge density unique to CaSR.
