Fig. 1: Schematic illustration to show the preparation of Mg galvanic cell (MgG) for tumor microenvironment modulation and enhanced cancer hydrogen therapy.
MgG is developed by decorating platinum on the surface of Mg rods, which allows the continuous generation of H2 in an aqueous environment due to galvanic-cell-accelerated water etching of Mg. By implanting MgG rods into a tumor, H2 molecules can be generated within the tumor, which induces mitochondrial dysfunction and intracellular redox homeostasis destruction. Meanwhile, the Mg(OH)2 residue can neutralize the acidic tumor microenvironment (TME). Such MgG rods with the micro-galvanic cell structure enable hydrogen therapy to inhibit the growth of tumors.
