Fig. 6: BEM interaction with antigen in SCS affects response to antigenic variants. | Nature Communications

Fig. 6: BEM interaction with antigen in SCS affects response to antigenic variants.

From: Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift

Fig. 6

a Design of antigenic drift experiment using variants of the NIP hapten. b NIP-specific and TNP-specific IgG1 antibody titer and affinity in ACKR4+/− and ACKR4−/− mice. Merged data from 4 independent experiments with five mice each (total n = 20). Boxes show medians and 50% range, whiskers: 5–95%. Symbols represent individual mice. Two-tailed Mann-Whitney test, ****p < 0.0001.

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