Fig. 2: Cit-k loss differentially affects dorsal and ventral OPCs in the postnatal mouse forebrain. | Nature Communications

Fig. 2: Cit-k loss differentially affects dorsal and ventral OPCs in the postnatal mouse forebrain.

From: Molecular and functional heterogeneity in dorsal and ventral oligodendrocyte progenitor cells of the mouse forebrain in response to DNA damage

Fig. 2

a NG2+ (red) cells in distinct regions of WT vs. Cit-k KO mouse forebrain. DAPI (blue) counterstains cell nuclei. Scale bar: 20 µm. b–e NG2+ cell density in the dorsal cortex (b), corpus callosum (c), striatum (d), and preoptica area (e) at P3 and P14 (n = 5 each; Two-way Anova followed by Bonferroni’s Multiple Comparison Test, Dors. Ctx: Genotype effect: P < 0.0001; Time effect: P < 0.0001; Genotype × Time: P = 0.0013. CC: Genotype effect: P < 0.0001; Time effect: P < 0.0001; Genotype × Time: P < 0.0001. Str: Genotype effect: P < 0.0001; Time effect: P = 0.0096; Genotype × Time: n.s. POA: Genotype effect: P < 0.0001; Time effect: n.s.; Genotype × Time: n.s.). Data are mean ± SE. CC corpus callosum, Dors. Ctx. dorsal cortex POA, preoptica area, P postnatal day, WT wild-type. ***P < 0.001; **P < 0.01, *P < 0.05. Source data are provided as a Source Data file.

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