Fig. 5: G protein coupling of VIP2R.
From: A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2
a Comparison of G protein coupling among VIP2R (PDB code: 7VQX), VIP1R (PDB code: 6VN7), PAC1R (PDB code: 6P9Y)16 and GLP-1R (PDB code: 6X18)24. The receptors and G proteins are colored as the labels. b Interaction between VIP2R and the C terminus of Gαs. c–h Comparison of the interactions between ICL2 and Gαs for VIP2R (PDB code: 7VQX), VIP1R (PDB code: 6VN7), and PAC1R (PDB codes: 6P9Y, 6LPB, 6M1H, and 6M1I)14,15,16. Residues involved in the interactions are shown as sphere and Gαs is shown as surface.
