Fig. 3: The active state GPR88 and the water-mediated hydrogen-bonding network.
From: Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex
a The active conformation of T6.48 and the Q5.50-L3.40-F6.44 triad. b The N7.49P7.50xxY7.53 motif and two water molecules in the receptor core. c The electron densities of the two water molecules and surrounding residues. d–f Water-mediated hydrogen-bonding networks in the active GPR88 (d), rhodopsin (e, PDB: 2 × 72), and the μOR (f, PDB: 5C1M). Polar interactions are highlighted as dash lines.
