Fig. 5: GPR88-Gi1 interface.
From: Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex
a Comparison of the GPR88-Gi1 complex with or without 2-PCCA. Red arrows indicate the shift of G-protein. b, c Superimposition of the receptor G-protein coupling interfaces for GPR88-Gi1, rhodopsin-Gi1 (PDB:6CMO), μOR-Gi1 (PDB:6DDE), α2BAR-Gi1 (PDB:6K42), and A1R-Gi2 (PDB:6D9H). d Interactions of GPR88 with the α5 helix of Gαi1. e Rotated view of interactions of GPR88 with the α5 and αN helices of Gαi1. Polar interactions are highlighted as dash lines.
