Fig. 2: Genome-wide associations for LDL-C. | Nature Communications

Fig. 2: Genome-wide associations for LDL-C.

From: Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits

Fig. 2

Miami plot showing summary data for Stage 1 GWAS (AWI-Gen, downward facing, N = 10,603) and Stage 2 GWAS (meta-analysis of AWI-Gen and four African cohorts, upward facing, N = 23,718). P-values (two-tailed, not adjusted for multiple comparisons, calculated using BOLT-LMM for Stage 1 GWAS and METASOFT for Stage 2 GWAS) are truncated at 10−20 for clarity. The red horizontal lines show the genome-wide significance threshold (5 × 10−8) and SNPs with P-values below this threshold are shown in orange. The loci corresponding to the region showing novel association in Stage 1 and Stage 2 GWAS are indicated in red. Other possible novel loci that reached genome-wide significance only in the Stage 2 analysis are shown in purple. Known LDL-C associated regions that were represented by novel lead SNPs are shown in green. Loci represented by lead SNPs that are well-known for LDL-C associations across multiple studies, including ours, are shown in black.

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